Romantic relationships confer numerous health benefits to individuals, including reducing mental health problems and improving physical health. Sexual and gender minority individuals experience unique stressors in their romantic relationships (e.g., discrimination), but evidence suggests that SGM relationships are just as important to individual health as they are for heterosexuals. At the same time, data suggests that a large proportion of new HIV infections occur in the context of romantic relationships, and this is particularly true among young sexual minority men in relationships. This presentation will summarize a series of studies evaluating 2GETHER, a couple-based relationship education and HIV prevention program for young sexual and gender minorities in the United States. The talk will review findings from two randomized controlled trials and an ongoing implementation-effectiveness trial, includes evaluations of telehealth and eHealth adaptations of the intervention.